I'm running Guix on my personal desktop, my personal server, and my work laptop. I'm using the nonguix channel on all three of them, it has been perfectly fine for me.

My servers NICs actually are not even supported by the Linux-libre kernel. I got around that by building a custom installer iso with the mainline Linux kernel. That probably sounds awful, but I have never built a bootable iso for any other distro before, and it was a breeze for me.