Space is almost certainly permanently inhospitable to what we call life. Apart from far flung oasises like Earth. Which would likely require entire star systems worth of resources and eons of time to send anything tangible between them.
I would generally agree with your second point; without a fundamental change in our understanding of physics, interstellar travel is unlikely. But I don’t really follow the logic of your first point, earth is just one of many bodies in space. What exactly would make orbital habitats, Lunar or Martian colonies, Martian terraforming, etc, fundamentally impossible?
Also, in regards to "what we call life", I would note we are already familiar with organisms that can survive in space (tardigrades), and our rapidly growing knowledge of biology and genetics opens a future in which we may be able to apply biological changes that would allow us to thrive in a wider range of environments.
