Oh yes absolutely! For example last time I checked libmusl, you didn't need -lrt, -ldl, -lcrypt nor a few others which I forgot about. It just provides empty stubs for those so that you can use the same build options as you regularly use with glibc. However for me threads were not supported (it was on a MIPS, lacking some 64-bit atomic ops haproxy relies on). So I'd be tempted to suggest having less options by default with musl since it's mostly aimed at embedded systems, and leaving it to users to choose if they want to enable more or not.

Correction: this requires to add -latomic there (just tested). I should mention this in the INSTALL file.