The linuxCNC project[1] is a distribution based on the real time kernel extensions for debian for real time cnc machine control. It used to be possible to get few-us guaranteed latency, but with modern multicore machines you are stuck with about 100us due to the way the caching works. Still plenty fast enough for audio!
Carefully-worded question: If OP is describing a single monolithic music production application, how does "+ Jack audio server" make the system more appropriate for meeting soft-realtime scheduling deadlines?