iTerm2 already has the feature where you click on a filename and it opens the file. If you're running a newish iTerm2, give it a go: do an ls, then command click.
I've called it Semantic History. It also let's you drag files out of the terminal as well. Old video walkthrough: http://vimeo.com/21872771
It does not require any special ls. As long as there's a legit filename, it should work.
Heh, that was a fun one to figure out. When digging around in iTerm2 source, I found out that you can figure out the current working directory of the shell, so that was relatively easy.
The hard part was my goal of getting it to work even if you change the working directory, so that paths that were legit before stay legit. I found out that my shell sends an escape code that updated the terminal title when it changed directories, so I hooked it into that, but it turns out that's oh-my-zsh specific.
I also added the ability for it to work even with spaces, which is essentially a brute-force, so it's not pretty.
I've called it Semantic History. It also let's you drag files out of the terminal as well. Old video walkthrough: http://vimeo.com/21872771
It does not require any special ls. As long as there's a legit filename, it should work.