It’s the complete disregard of typesetting in ebooks that has always repelled me. I fundamentally reject the notion that all books can be reduced to text files. Design matters!
I only read works consisting purely of prose on ebooks, mostly fiction. They are rubbish for text books for at least a couple of reasons:
1. The typesetting, as you point out. Books are carefully typeset for the size of the pages they are printed on. Screens are going to be completely the wrong size/shape for most things,
2. Seek speed. Seeking to a point in an ebook is excruciating. A real book is by far the best format for quickly seeking to a place or seeking backwards and forwards between multiple pages. I can also open two books at once and seek between them using only my eyes.